Confirming what many will have experienced first hand, psychologists found hungover people had worse attention and memory, as well as slower speed and co-ordination.
Researchers at the University of Bath say their findings have important implications for activities such as driving.
Their results suggest that even if drivers wait until they think the alcohol has left the body, their skills could still be dangerously sluggish and below par.
People in certain jobs could also underperform, and the psycologists say some employers may want to consider changing health and safety guidelines when it comes to hungover employees coming into work.
Hangovers are already estimated to cost the UK economy £1.9bn a year but little research has been done on being hungover "on the job".
Lead author Craig Gunn said: "In our review of 19 studies we found that hangovers impaired psychomotor speed, short and long-term memory and sustained attention.
"Impaired performance in these abilities reflects poorer concentration and focus, decreased memory and reduced reaction times the day after an evening of heavy drinking."
Senior author Dr Sally Adams added: "Our findings demonstrate that a hangover can have serious consequences for the performance of everyday activities such as driving and workplace skills such as concentration and memory.
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